The aim of present work is to provide transdermal delivery of rasagiline provides more beneficial drug delivery over oral drug delivery system. Transdermal patch offer the advantages such as maintenance of controlled and prolong drug level, reduced frequency of dosing, minimization of inter and intrapatient variability, self administration, and easy termination of medication during treatment due to side effects observed leading to patient compliance, directly systemic delivery prevent drug related side effects. Rasagiline transdermal patch made from different types of pressure sensitive polymers like acrylic adhesive, polyisobutylene adhesive and silicon adhesives. It was evaluated a combination of pressure sensitive adhesive to optimize skin permeation and physical property of rasagiline patch. It was found that silicone type PSA formulation has zero order release pattern. Physical properties of different formulations were evaluated in terms of peel, tack and shear. All formulations were stable during 28 days study and reflects physical stability of formulations. Combination of silicone PSAs has better physical property and controlled drug release profile. A combination of silicon type pressure sensitive adhesive can be use to prepare stable formulation of rasagiline with zero order controlled release profile.
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